frequency of mutation मीनिंग इन हिंदी

उदाहरण वाक्य

1. Cancers have high levels of genome instability, associated with a high frequency of mutations.
2. The frequency of mutations differs for various ethnicities, depending on the origin of the mutation.
3. Among 20 cancers evaluated, mismatch repair deficient microsatellite instable ( MSI ) colon cancer had the second highest frequency of mutations ( after melanoma ).
4. Epigenetic defects in DNA repair may thus contribute to the characteristic high frequency of mutations in the genomes of cancers, and cause their carcinogenic progression.
5. When DNA repair is deficient DNA damages remain in cells at a higher than usual level and these excess damages cause increased frequencies of mutation or epimutation.
6. Cancers also generally have genome instability, that includes a high frequency of mutations in the noncoding DNA that makes up about 98 % of the human genome.
7. Among 20 cancers evaluated, microsatellite instable ( MSI ) colon cancer ( mismatch repair deficient ) had the second highest frequency of mutations ( after melanoma ).
8. In cells stressed oxidatively, Colostrinin reduced the frequency of mutation induced by reactive oxygen species ( ROS ) to nearly background levels in a dose-dependent manner.
9. Likewise, Colostrinin reduced the frequency of mutation caused by two mutagenic agents, methyl methane sulfonate and mitomycin-C, the latter often used in cancer chemotherapy.
10. When expression of DNA repair genes is reduced, DNA damages accumulate in cells at a higher than normal level, and such excess damages cause increased frequencies of mutation.